Week 5 NFL Injury Recap & Analysis: Saquon Barkley leaves with ankle sprain, Clyde Edward-Helaire likely to miss significant time with knee injury October 11, 2021 by Pro Football Focus Saquon Barkley and Clyde Edwards-Helaire top the list of Week 5 NFL injuries that will impact fantasy football rankings and free agent strategy heading into Week 6 of the 2021 NFL season.